Detective Sergeant Darren Barker was admitted to hospital in late January and passed away on Friday surrounded by his family.
He started with the Metropolitan Police in March 1992 and was described by a colleague as an “extremely talented detective”.
The officer was classed as vulnerable and had been shielding.
DS Barker worked from home during the pandemic on a number of investigations, Scotland Yard said.
He even played a lead role in an ongoing, highly complex multi-national money laundering probe, which resulted in its first conviction last month.
DS Barker is survived by parents Eric and Sheila, wife Caroline, two adult children Christian and Lauren. His brother Eric Barker is a serving constable in north London.
Detective Chief Superintendent James Harman, from the Met’s Specialist Operations Command, said: “Darren was a much loved and respected friend and colleague for so many of us across the Met.
“He was well known for his sense of humour and his positive, gentle nature – but also for his incredible work ethic, professionalism and dedication to duty throughout his long career as a police officer.
“Darren was an extremely talented detective. Despite the challenges of shielding he continued to work on a number of high-profile complex investigations, and his leadership during these investigations was truly invaluable.
“He will be remembered fondly by everyone he worked with, and will be greatly missed by us all. We are truly saddened by his loss and our thoughts are with his family and friends at this difficult time.”