The Three Lions were 1-0 losers to Denmark in their last fixture in the competition, meaning they dropped to third in League A Group 2 with the same number of points as the Danes but two fewer than leaders Belgium.
England, who overcame Belgium 2-1 in the reverse fixture of Sunday’s meeting, could go top of the mini-table by taking three points against Roberto Martinez’s team in Heverlee.
That will also depend on the result of Denmark’s clash with bottom Iceland, however.
Here’s everything you need to know about the game:
Kick-off is at 7.45pm BST on Sunday.
The match will air live on Sky Sports Main Event and Sky Sports Premier League, with coverage beginning at kick-off on the first of those channels and 7pm BST on the latter.
Belgium goalkeeper Thomas Kaminski, a late call-up, has withdrawn from the hosts’ squad after testing positive for Covid-19.
Meanwhile, Wolves defender Conor Coady has left the England camp after testing positive for coronavirus, and Manchester United striker Marcus Rashford will miss out through injury. Liverpool centre-back Joe Gomez’s knee injury, sustained in training this week, keeps him out for the foreseeable future, too.
Belgium: Mignolet, Alderweireld, Vertonghen, Denayer, Tielemans, Dendoncker, Chadli, T. Hazard, Praet, Lukaku, Batshuayi
England: Pickford, Keane, Maguire, Mings, James, Chilwell, Rice, Grealish, Kane, Calvert-Lewin, Sancho
This weekend get a £10 free bet with Betfair, when you bet £10 on a Same Game Multi on the Premier League. Terms: Min £10 Same Game Multi bet on any EPL match this Fri – Sun. Free bet valid for 72 hours, awarded at bet settlement. Excludes cashed out bets. T&Cs apply.