From: Fralin Life Sciences Institute
Gianluca Tosini, professor and chair of the Department of Pharmacology and Toxicology at the Morehouse School of Medicine, will speak at the Virginia Tech Life Science Seminar (VTLSS) on Friday, Sept. 24, at 12:00 p.m. VTLSS is a university-wide seminar series funded by the Fralin Life Sciences Institute at Virginia Tech.
When: Friday, Sept. 24, at 12:00pm
Where: Fralin Hall Auditorium; Live on Youtube
Title: “Understanding melatonin receptor function: Latest insights from mouse models, and their relevance to human disease”
Abstract: Melatonin, the neuro-hormone synthesized during the night, has recently seen an unexpected extension of its functional implications toward type 2 diabetes development, visual functions, sleep disturbances, and depression. Transgenic mouse models were instrumental for the establishment of the link between melatonin and these major human diseases. Most of the actions of melatonin are mediated by two types of G protein-coupled receptors, named MT1 and MT2, which are expressed in many different organs and tissues. Understanding the pharmacology and function of mouse MT1 and MT2 receptors, including MT1/MT2 heteromers, will be of crucial importance to evaluate the relevance of these mouse models for future therapeutic developments. My talk will critically discuss these aspects, and give some perspectives including the generation of new mouse models.
Watch the seminar live: youtube.com/user/fralinlifescience/live