La Liga will return on June 11 with the Andalusian derby before Barcelona get their season back underway 48 hours later.
Sevilla and Real Betis will renew their rivalry at the Ramón Sánchez Pizjuán on the Thursday night.
Current table toppers Barcelona travel to Real Mallorca on the Saturday looking to maintain their two-point lead.
Their last outing before the coronavirus-enforced break was a 1-0 win over Real Sociedad which came after a Clasico defeat at the Bernabeu.
Real Madrid play 24 hours after their rivals and will aim to keep up the chase when they take on Eibar in the capital.
Los Blancos have won just one La Liga title since 2012 – back in 2017 under Zinedine Zidane.
Since then they have had to watch Barcelona win successive titles under Ernesto Valverde.
But an inconsistent year cost him his job and he was replaced by Quique Setien who has been tasked with sealing a hat-trick of league triumphs.
The battle for Europe is also hotting up in Spain with third-placed Sevilla and Valencia in seventh separated by just five points.
Sociedad currently occupy the last Champions League spot and take on Osasuna in the weekend’s final game.
Atletico Madrid, whose last outing was their memorable 3-2 win at Anfield in the Champions League, head to San Mames to take on Athletic Bilbao.
Getafe take on Granada in one of two games on Friday night with Valencia’s derby clash against Levante the other.
Celta Vigo vs Villarreal and Real Valladolid’s trip to Leganes are the two other fixtures being played on La Liga’s return.