Palace were 3-1 winners when the sides met earlier this season, with former United man Wilfried Zaha netting a double and Andros Townsend also getting on the scoresheet.
Entering tonight’s fixture, United are second in the top-flight table, while Palace are 13th. Both teams have won two of their last five, though United have three draws to go along with those victories, whereas Roy Hodgson’s players have lost two and drawn one of their other games in that run.
Here’s everything you need to know ahead of tonight’s match.
The game will kick off at 8.15pm this evening.
The match will air live on Sky Sports, with subscribers also able to stream it live on the Sky Sports website and SkyGo app.
Edinson Cavani might not return to full fitness in time for tonight’s game, while Paul Pogba, Juan Mata and Phil Jones also remain out.
For Palace, Zaha will miss out alongside a number of other first-team players, including James McArthur, Connor Wickham, Jeffrey Schlupp, Mamadou Sakho, Wayne Hennessey, Nathan Ferguson and James Tomkins. Nathaniel Clyne could return here, however.
Palace: Guaita; Ward, Kouyate, Cahill, Van Aanholt; Milivojevic, Riedewald; Townsend, Eze, Ayew; Mateta
United: De Gea; Wan-Bissaka, Bailly, Maguire, Telles; Matic, Fred; James, Fernandes, Rashford; Martial
United’s form has waned somewhat in recent weeks but they should rebound here with a win. Palace 1-2 United.