The Argentine boss was backed at odds as low as 1/6 to depart the north London club before the end of September.
The “high volume” of punts forced Coral to pull the plug on the market in potentially worrying news for Spurs fans.
Spokesman for Coral, John Hill, said: “This is a gamble which has taken us by surprise and as a result of the volume of bets we have taken, we have had no choice but to suspend betting to let the dust settle as there is rarely smoke without fire when it comes to such activity in our managerial markets.
The news comes following a summer where Pochettino has made several digs aimed at the club’s hierarchy over transfer dealings and rumours of discontent.
Speculation continues to surround the future of key player Christian Eriksen who could be sold before Monday’s deadline with his contract in its final year.
Pochettino previously admitted to there being several unrests within his squad with Tottenham have had an indifferent start to the new season.
As recently as last Sunday, Pochettino told Football London : “This is my sixth season and the most unsettled group we are working with.
“That is why we are relaxed and calm. Some situations we cannot fix. Nothing to say about that, situations that are going on in the squad. Still we need to wait.
“That is the circumstances after playing the Champions League on June 1, we knew that some situations like this would happen but for us and the club it’s difficult to handle.
“What can we do? We can only wait. I say again, you have for sure more information than me about what’s happening in the market.
“That’s why I cannot do more than try to help the team find the best dynamic to train and not to create too many problems and be a person who is not being very emphatic, but understand every single situation and try to get a good result.
“This type of stuff happens in the Premier League and that’s why you not only need quality players, you need a very good dynamic, and strong team bond and at the moment that situation in our group is still far, far away from what we expect.”
Pochettino hinted at the end of last season that he could walk away from Spurs and suggested winning the Champions League would be a fitting way to bow out.
Ahead of June’s final with Liverpool , he said: “It should be fantastic, no? Close the five-year chapter and go home.”
The Argentine boss only signed a new contract with Spurs last year which committed him to the club until 2023.